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Table 4 Predictive value of malnutrition indices for long-term clinical worsening

From: Effects of malnutrition on disease severity and adverse outcomes in idiopathic pulmonary arterial hypertension: a retrospective cohort study

 

Unadjusted

Model 1a

Model 2b

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

GNRI

 Per 1-SD increasement

0.827 (0.702, 0.975)

0.024

0.861 (0.723, 1.025)

0.0917

0.964 (0.807, 1.150)

0.681

 Normal

1 [Reference]

 

1 [Reference]

 

1 [Reference]

 

 Mild

1.068 (0.704, 1.620)

0.758

1.006 (0.655, 1.548)

0.977

0.762 (0.479, 1.210)

0.249

 Moderate-Severe

1.822 (1.092, 3.041)

0.022

1.622 (0.939, 2.800)

0.083

1.162 (0.654, 2.062)

0.609

PNI

 Per 1-SD increasement

0.835 (0.710, 0.982)

0.029

0.858 (0.726, 1.015)

0.073

0.934 (0.785, 1.110)

0.436

 Normal

1 [Reference]

 

1 [Reference]

 

1 [Reference]

 

 Malnutrition

0.955 (0.547, 1.668)

0.873

0.788 (0.445, 1.395)

0.414

0.586 (0.32, 1.073)

0.083

CONUT

 Per 1-SD increasement

1.480 (1.285, 1.705)

 < 0.001

1.489 (1.286, 1.723)

 < 0.001

1.363 (1.147, 1.619)

 < 0.001

 Normal

1 [Reference]

 

1 [Reference]

 

1 [Reference]

 

 Mild

3.550 (1.738, 7.252)

 < 0.001

3.699 (1.800, 7.602)

 < 0.001

2.817 (1.356, 5.851)

0.006

 Moderate-Severe

5.142 (2.147, 12.317)

 < 0.001

4.973 (2.062, 11.992)

 < 0.001

3.000 (1.158, 7.770)

0.024

  1. aModel 1: Adjusted for age, sex, ethnicity, and BMI (Categorical)
  2. bModel 2: Adjusted for age, sex, ethnicity, BMI (Categorical), WHO-FC, 6MWD, ln (NT-proBNP), PAH specific medication, SVO2, cardiac index and PVR
  3. CI confidence interval, CONUT controlling nutritional status, GNRI geriatric nutritional risk index, HR hazard ratio, ln logarithmically transformed, NT-proBNP N-terminal pro-brain natriuretic peptide, 6MWD 6-min walk distance, PAH pulmonary arterial hypertension, PNI prognostic nutritional index, PVR pulmonary vascular resistance, SvO2 mixed venous oxygen saturation, WHO-FC World Health Organization functional class
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Respiratory Research

ISSN: 1465-993X

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