Fig. 1
From: The role of extracellular traps released by neutrophils, eosinophils, and macrophages in asthma

Schematic diagram of NETs formation. There are two pathways of NETs formation. Suicidal NETosis includes chromatin decondensation, the disintegration of nuclear membranes, and the release of the nuclear-cytoplasmic mixture. Vital NETosis is characterized by releasing eDNA via vesicle budding. PMA, phorbol-12-myristate-13-acetate; IL-8, interleukin-8; LPS, lipopolysaccharide; NE, neutrophil elastase; Cath G, cathepsin G; MPO, myeloperoxidase; CitH3, citrullinated histone 3