Table 2 Moderate or severe exacerbations: EOS count subgroups by exacerbation history and COPD severity, mITT population

EOS 100 to < 300 cells/mm³

Without exacerbation history in the preceding 12 months

N = 308

N = 307

N = 147

 Patients with exacerbations, n (%)

45 (14.6)

76 (24.8)

24 (16.3)

 Events^a

50

99

25

 Total time at risk, years

131.31

126.63

61.30

 Adjusted COPD exacerbation rate (SE)^b

0.35 (0.06)

0.79 (0.10)

0.38 (0.09)

With exacerbation history in the preceding 12 months

N = 102

N = 92

N = 45

 Patients with exacerbations, n (%)

22 (12.6)

32 (34.8)

16 (35.6)

 Events^a

31

41

19

 Total time at risk, years

43.51

37.14

17.61

 Adjusted COPD exacerbation rate (SE)^b

0.64 (0.14)

1.13 (0.23)

1.04 (0.31)

Moderate COPD

N = 201

N = 204

N = 90

 Patients with exacerbations, n (%)

25 (12.4)

44 (21.6)

17 (18.9)

 Events^a

29

50

20

 Total time at risk, years

86.54

86.71

36.38

 Adjusted COPD exacerbation rate (SE)^b

0.29 (0.06)

0.55 (0.09)

0.51 (0.13)

Severe COPD

N = 182

N = 163

N = 89

 Patients with exacerbations, n (%)

37 (20.3)

52 (31.9)

22 (24.7)

 Events^a

47

66

23

 Total time at risk, years

77.54

65.04

37.12

 Adjusted COPD exacerbation rate (SE)^b

0.55 (0.10)

1.10 (0.18)

0.62 (0.16)

Very severe COPD

N = 26

N = 32

N = 12

 Patients with exacerbations, n (%)

5 (19.2)

12 (37.5)

1 (8.3)

 Events^a

5

24

1

 Total time at risk, years

10.27

12.01

4.94

 Adjusted COPD exacerbation rate (SE)^b

0.43 (0.24)

1.47 (0.50)

0.15 (0.17)

EOS ≥ 100 cells/mm³

Without exacerbation history in the preceding 12 months

N = 363

N = 368

N = 179

 Patients with exacerbations, n (%)

51 (14.0)

90 (24.5)

27 (15.1)

 Events^a

60

128

28

 Total time at risk, years

155.06

149.63

74.46

 Adjusted COPD exacerbation rate (SE)^b

0.36 (0.057)

0.93 (0.117)

0.35 (0.081)

With exacerbation history in the preceding 12 months

N = 119

N = 116

N = 53

 Patients with exacerbations, n (%)

27 (22.7)

43 (37.1)

18 (34.0)

 Events^a

37

64

22

 Total time at risk, years

50.55

46.12

21.25

 Adjusted COPD exacerbation rate (SE)^b

0.69 (0.148)

1.53 (0.278)

1.07 (0.310)

Moderate COPD

N = 245

N = 250

N = 113

 Patients with exacerbations, n (%)

29 (11.8)

62 (24.8)

19 (16.8)

 Events^a

34

90

23

 Total time at risk, years

105.78

103.10

46.29

 Adjusted COPD exacerbation rate (SE)^b

0.28 (0.06)

0.92 (0.14)

0.45 (0.12)

Severe COPD

N = 205

N = 198

N = 104

 Patients with exacerbations, n (%)

43 (21.0)

59 (29.8)

24 (23.1)

 Events^a

57

78

25

 Total time at risk, years

87.15

78.77

43.16

 Adjusted COPD exacerbation rate (SE)^b

0.60 (0.10)

1.05 (0.16)

0.61 (0.15)

Very severe COPD

N = 30

N = 36

N = 14

 Patients with exacerbations, n (%)

6 (20.0)

12 (33.3)

2 (14.3)

 Events^a

6

24

2

 Total time at risk, years

11.75

13.87

5.80

 Adjusted COPD exacerbation rate (SE)^b

0.45 (0.25)

1.30 (0.46)

0.29 (0.24)