The cGAS-STING pathway in COPD: targeting its role and therapeutic potential

Respiratory Research

Table 1 cGAS and STING antagonists

cGAS and STING Antagonists	Name	Molecular mechanism	References
cGAS inhibitors	Hydroxychloroquine	Disrupting DNA binding	[69]
	Quinacrine		[69]
	X6		[70]
	A151		[71]
	Suramin		[72]
	RU.521	Occupying cGAS Catalytic site	[73]
	PF-06928125		[74]
STING inhibitors	Tetrahydroisoquinolinone acetate (Compound 18)	Targeting the CDN-binding site	[75]
	Astin C		[76]
	Nitrofuran derivatives(C-170, C-171, etc.)	Targeting STING palmitoylation sites	[77]
Unknown inhibitors	CU-32 and CU-76	unknown mechanisms	[78]
	VS-X4		[79]

ISSN: 1465-993X