Fig. 7
A proposed model of the role of TNKS1BP1/CNOT4/EEF2 pathway on AECII senescence and RILI. Under radiation, TNKS1BP1 directly interacted with CNOT4 and down-regulates its expression, thereby inhibit the degradation of EEF2, facilitates AECII senescence, finally induce the RILI