Table 3 SDB groups. All data are presented as Median [Q1;Q3]
OSA (N 1) | CSA (N 9) | SSH (N 4) | No-SDB (N 14) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Baseline | 1-year | p.value | Baseline | 1-year | p.value | Baseline | 1-year | p.value | Baseline | 1-year | p.value | |||||||||
Lung function test | ||||||||||||||||||||
BMI | 28.5 [27;33.43] | 29.29 [27.42;33.43] | 0.464 | 26 [25;30.06] | 25.82 [23.5;30.06] | 0.250 | 28.5 [26.75;28.4] | 26.48 [24.6;28.4] | 0.125 | 27 [25.45;28.47] | 26.53 [25.6;28.47] | 0.391 | ||||||||
FVC (mL) | 2800 [2370;3167.5] | 2780 [2172.5;3167.5] | 0.132 | 2790 [2640;3440] | 2810 [2480;3440] | 0.652 | 2060 [1997.5;2427.5] | 2020 [1910;2427.5] | 1.000 | 2310 [1907.5;3290] | 2360 [1790;3290] | 0.432 | ||||||||
FVC (%) | 92.5 [86.75;113.75] | 90 [83.5;113.75] | 0.363 | 101 [83;117] | 108 [78;117] | 0.343 | 72 [62.25;84] | 71.5 [61.25;84] | 0.250 | 97 [93;105.75] | 99 [85.25;105.75] | 0.615 | ||||||||
FEV1/FVC | 81.98 [78.26;84.33] | 80.31 [78.1;84.33] | 0.632 | 82.62 [74.46;83.9] | 78.52 [69.7;83.9] | 0.027 | 80.91 [79.05;88.99] | 83.21 [79.09;88.99] | 1.000 | 82.75 [78.74;88.34] | 84.75 [76.95;88.34] | 0.903 | ||||||||
TLC (mL) | 4430 [3960;4640] | 4180 [3700;4640] | 0.083 | 4790 [4390;5730] | 4820 [4150;5730] | 0.359 | 3310 [3250;3660] | 3470 [3250;3660] | 0.773 | 4240 [2930;4730] | 4080 [2960;4730] | 0.162 | ||||||||
TLC (%) | 77 [73.5;83] | 74 [71;83] | 0.123 | 77 [71;91] | 86 [67;91] | 0.301 | 62 [60;70] | 67 [64;70] | 1.000 | 80 [71;80] | 73 [70;80] | 0.233 | ||||||||
DLCO (%) | 56.5 [53.25;70.25] | 56 [49.5;70.25] | 0.029 | 51 [46;77] | 58 [42;77] | 0.552 | 71 [60;65] | 57 [49;65] | 0.371 | 62.5 [49.5;60.25] | 55 [45.75;60.25] | 0.012 | ||||||||
KCO (%) | 82.5 [69.75;103.25] | 89 [72;103.25] | 0.518 | 81 [65;103] | 77 [71;103] | 0.905 | 97 [95.5;114.5] | 99 [93;114.5] | 1.000 | 84 [79.5;86] | 79.5 [77.75;86] | 0.024 | ||||||||
6MWD distance (m) | 431.5 [391;492] | 437 [377;492] | 1.000 | 433 [423;447] | 423 [384;447] | 0.734 | 374.5 [341;382.5] | 329 [293;382.5] | 0.789 | 435 [398.25;446.25] | 416.5 [355.75;446.25] | 0.069 | ||||||||
6MWD minimal SpO2% | 90.5 [87.75;95] | 90.5 [88.75;95] | 0.861 | 92 [90;96] | 93 [91;96] | 0.325 | 90.5 [88;90.5] | 90 [90;90.5] | 0.875 | 92 [89.75;93.75] | 90.5 [87;93.75] | 0.423 | ||||||||
Blood biological mediators | ||||||||||||||||||||
CRP | 7.3 [3.5;10.62] | 6.5 [2.2;10.62] | 0.045 | 2.2 [1.6;5.7] | 1.1 [0.7;5.7] | 0.496 | 6.05 [3.47;3] | 2.7 [2.22;3] | 0.250 | 2.1 [1.35;3.28] | 2.1 [1.22;3.28] | 0.485 | ||||||||
LDH | 200.5 [170.25;211.25] | 194.5 [169.75;211.25] | 0.856 | 203 [190;214] | 204 [177;214] | 0.129 | 166 [158.5;167] | 154 [153;167] | 1.000 | 200 [179.75;233.5] | 193 [173.5;233.5] | 0.576 | ||||||||
NT-BNP | 83 [25.5;214.5] | 187 [169.5;214.5] | 0.229 | 214 [135;214] | 204 [177;214] | 0.734 | 32 [25.5;167] | 154 [153;167] | 0.250 | 81 [31;236] | 198 [175;236] | 0.002 | ||||||||
IL-6 | 11.52 [7.18;27.52] | 17.62 [11;27.52] | 0.029 | 9.85 [8.83;36.74] | 12.56 [11.34;36.74] | 0.02 | 11.74 [10.45;15.56] | 13.87 [11.66;15.56] | 0.875 | 8.59 [6.5;17.11] | 9.49 [7.22;17.11] | 0.042 | ||||||||
MMP-1 | 8.75 [6.12;7.92] | 7.02 [5.27;7.92] | 0.029 | 10.2 [7.5;9.98] | 6.91 [5.01;9.98] | 0.027 | 5.6 [5.25;10.11] | 7.31 [5.05;10.11] | 1.000 | 7.5 [6.12;11.5] | 6.98 [4.59;11.5] | 0.391 | ||||||||
MMP-7 | 5.54 [4.35;7.37] | 5.71 [4.65;7.37] | 0.495 | 7.73 [6.74;7.98] | 6.83 [5.94;7.98] | 0.57 | 6.25 [5.73;8.22] | 6.84 [6.18;8.22] | 0.875 | 5.4 [5.17;7.28] | 5.77 [4.75;7.28] | 0.67 | ||||||||
MMP-9 | 240.06 [186.99;591.38] | 487.24 [413.61;591.38] | < 0.001 | 348.2 [293.95;776.08] | 640.07 [605.72;776.08] | 0.004 | 246.55 [206.21;590.34] | 411.6 [268.01;590.34] | 0.625 | 161.82 [125.18;439.26] | 306.89 [228.73;439.26] | < 0.001 | ||||||||
FNIII-C | 92.93 [73.01;184.53] | 151.48 [131.58;184.53] | < 0.001 | 103.67 [85.76;261.14] | 193.72 [109.59;261.14] | 0.055 | 96.58 [89.8;191.3] | 153.66 [131.12;191.3] | 0.250 | 97.27 [69.48;194.79] | 174.92 [125.97;194.79] | < 0.001 | ||||||||
AGEs/RAGEs | 15.03 [9.64;20.88] | 12.07 [8.92;20.88] | 0.86 | 17.63 [15.82;18.54] | 10.91 [6.58;18.54] | 0.027 | 15.4 [9.87;21.59] | 14.39 [8.46;21.59] | 0.625 | 18.11 [15.69;16.95] | 12.31 [7.33;16.95] | 0.02 | ||||||||
SP-D | 12.67 [7.11;28.13] | 18.88 [12.16;28.13] | 0.562 | 43.4 [29.16;29.93] | 25.97 [15.77;29.93] | 0.074 | 25.06 [19.37;17.36] | 10.68 [5.68;17.36] | 0.250 | 22.34 [12.65;24.21] | 20.46 [11.65;24.21] | 0.626 | ||||||||
KL-6 | 804.5 [608.5;1242.25] | 882 [532.25;1242.25] | 0.782 | 856 [512;991] | 855 [599;991] | 0.213 | 410.5 [388.5;841.75] | 433 [390.25;841.75] | 0.375 | 797 [629.25;1227.75] | 897 [646.25;1227.75] | 0.626 | ||||||||
Sleep study | ||||||||||||||||||||
SE (%) | 71.75 [62.62;80.45] | 67.1 [61.7;80.45] | 0.453 | 74.1 [55.4;75] | 69.8 [51.1;75] | 0.91 | 67.8 [56.35;73.22] | 65.55 [55.9;73.22] | 1 | 78.1 [62.7;86.35] | 72.2 [64.6;86.35] | 0.577 | ||||||||
N1 (% TST) | 19.4 [15.2;14.95] | 12.95 [8.22;14.95] | 0.016 | 13.5 [4.9;22.8] | 16.1 [10.8;22.8] | 0.359 | 11.3 [8.57;19] | 13.5 [9.85;19] | 0.375 | 9.3 [6.85;15.8] | 14.1 [5.5;15.8] | 0.444 | ||||||||
N2 (% TST) | 39.4 [34.95;45.07] | 38.25 [28.9;45.07] | 0.669 | 36.9 [27.5;41.1] | 31.7 [31.4;41.1] | 0.91 | 32.6 [29.42;38] | 35.6 [31.83;38] | 0.625 | 38.4 [33.95;43.35] | 38.7 [35.75;43.35] | 0.45 | ||||||||
N3 (% TST) | 25.9 [16.55;38.03] | 28.15 [25.2;38.03] | 0.187 | 38.4 [32;31.3] | 26.6 [24.1;31.3] | 0.074 | 38.7 [32.6;38.05] | 30.55 [26.32;38.05] | 0.25 | 34.6 [21.4;36.7] | 33.6 [23.35;36.7] | 0.919 | ||||||||
REM (% TST) | 14.4 [6.7;21.88] | 16.5 [10.47;21.88] | 0.495 | 17.6 [9.3;20.3] | 20.1 [12.8;20.3] | 1 | 20.15 [15.82;18.22] | 15.9 [14.3;18.22] | 1 | 17.4 [12.05;21.55] | 17.4 [12.65;21.55] | 0.278 | ||||||||
AI (events/h) | 3.65 [1.57;0.35] | 0 [0;0.35] | < 0.001 | 10.27 [1.19;0.7] | 0 [0;0.7] | 0.021 | 0 [0;1.35] | 0.5 [0;1.35] | 0.423 | 0.63 [0;1.05] | 0.55 [0;1.05] | 0.919 | ||||||||
HI (events/h) | 20.47 [17.63;8.9] | 4.2 [1.53;8.9] | 0.002 | 24.46 [19.91;10.1] | 9.5 [4.1;10.1] | 0.008 | 11.36 [10.01;19.22] | 10.25 [3.17;19.22] | 0.875 | 6.37 [3.36;11.07] | 7.6 [4.62;11.07] | 0.091 | ||||||||
AHI (events/h) | 25.5 [21.23;9.28] | 4.2 [1.65;9.28] | < 0.001 | 30.4 [22.8;10.1] | 10.1 [4.8;10.1] | 0.004 | 11.45 [10.18;20.6] | 10.75 [3.17;20.6] | 1 | 7.2 [4.9;12.2] | 9.5 [5.3;12.2] | 0.146 | ||||||||
Mean SpO2 (%) | 94 [93;96] | 95 [93.75;96] | 0.008 | 93 [92;97] | 95 [94;97] | 0.121 | 92.5 [91.75;96.5] | 95 [94;96.5] | 0.098 | 95 [94;95.75] | 94.5 [93.25;95.75] | 0.198 | ||||||||
Lowest SpO2 (%) | 81 [78.75;91] | 89 [88;91] | 0.015 | 82 [80;89] | 86 [85;89] | 0.092 | 83.5 [82.75;87.75] | 86.5 [86;87.75] | 0.125 | 89 [88;88.75] | 86 [83.25;88.75] | 0.005 | ||||||||
ODI (events/h) | 19.55 [16.68;10.12] | 5 [2.42;10.12] | < 0.001 | 48.3 [23.2;11.5] | 7.4 [1.7;11.5] | 0.004 | 12.1 [9.58;12.57] | 6.4 [0.45;12.57] | 0.125 | 4.6 [2.42;9.53] | 5.2 [3.62;9.53] | 0.124 | ||||||||
TST90 (%) | 1.9 [1;0.45] | 0.1 [0;0.45] | 0.012 | 12.4 [4.7;2] | 0.1 [0;2] | 0.004 | 7.05 [6.33;0.8] | 0.4 [0;0.8] | 0.125 | 0.1 [0;1.65] | 0.1 [0;1.65] | 0.148 | ||||||||
TST88 (%) | 0.6 [0.18;0] | 0 [0;0] | 0.01 | 3.1 [0.8;0.2] | 0 [0;0.2] | 0.004 | 1.8 [1.8;0.12] | 0.05 [0;0.12] | 0.125 | 0 [0;0.2] | 0.05 [0;0.2] | 0.05 | ||||||||
TST88 (minutes) | 2.65 [0.75;0.03] | 0 [0;0.03] | 0.007 | 14.3 [5.2;1] | 0.1 [0;1] | 0.004 | 8.3 [7.85;0.62] | 0.3 [0;0.62] | 0.125 | 0 [0;0.95] | 0.25 [0;0.95] | 0.041 | ||||||||
PLM index | 2.9 [0;41.88] | 8.8 [0;41.88] | 0.059 | 0 [0;3.4] | 1 [0;3.4] | 0.281 | 0 [0;1.35] | 0 [0;1.35] | 1 | 0.8 [0;14.55] | 6.5 [0;14.55] | 0.042 | ||||||||