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Fig. 6 | Respiratory Research

Fig. 6

From: Statin administration or blocking PCSK9 alleviates airway hyperresponsiveness and lung fibrosis in high-fat diet-induced obese mice

Fig. 6

Effects of PCSK9 inhibition or statin administration on NLRP3 activity in HFD mouse lungs. Representative photomicrographs of caspase-1- and NLRP3- positive areas (A) in lung sections from mice of the different treatment groups are shown (50×). Quantification of NLRP3- (B) and caspase-1-(C) positive areas was performed using an image analysis system. Quantitative RT-PCR measurement of NLRP3 (D), ASC (E), caspase-1 (F), and IL-1β (G) mRNA expression in the lungs is shown. The results are expressed as the mean ± SEM (n = 6 per group). Statistical analysis was performed using one-way ANOVA with Bonferroni correction. *: P < 0.05, **: P < 0.01, and ***: P < 0.001

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Respiratory Research

ISSN: 1465-993X

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