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Fig. 2 | Respiratory Research

Fig. 2

From: Statin administration or blocking PCSK9 alleviates airway hyperresponsiveness and lung fibrosis in high-fat diet-induced obese mice

Fig. 2

Effects of PCSK9 inhibition or statin administration on AHR and airway inflammation in HFD-induced obese mice. (A) AHR was measured as the Rrs at 24 h after the final treatment. (B) Effect of the HFD on cell counts in BALF. Mice were sacrificed 24 h after the final treatment, and BALF cells were isolated. (C–H) IL-1β (C), IL-6 (D), IL-17a (E), IL-18 (F), TNF-α (G), and TGF-β (H) levels in lung homogenates and leptin (I) levels in serum were evaluated by ELISAs. The results are expressed as the mean ± SEM (n = 6 per group). Statistical analysis of AHR was performed using repeated-measures ANOVA, and other analyses were performed using one-way ANOVA with Bonferroni correction. *: P < 0.05, **: P < 0.01, and ***: P < 0.001

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Respiratory Research

ISSN: 1465-993X

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