Fig. 6
From: A novel quinoline with airway relaxant effects and anti-inflammatory properties
The effect of RCD405 treatment in LPS induced airway inflammation. Experimental groups: Veh/PBS (n = 5), RCD405/PBS (n = 5), Veh/LPS (n = 5), RCD405/LPS (n = 5). A Murine lung weights recorded on day 21. B Murine body weights at day 21 shown as percentage of starting weight. Total cells (C), neutrophils (D), inflammatory macrophages (E) and alveolar macrophages (F) in BALF at day 21. G, I and K Heatmaps showing cytokine and chemokine levels in lung homogenate, BALF and plasma. H, J and L Individual graphs of COPD related cytokines G-CSF, KC, and TNF-α. All individual cytokine graphs can be found in Supplementary Fig. 5–7. Statistical comparisons were performed using a one-way ANOVA followed by a Dunnett’s post-hoc test (*P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001)