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Table 3 MR results in urinary metabolites from cohort 1

From: Causal relationships of metabolites with allergic diseases: a trans-ethnic Mendelian randomization study

Outcome

Exposure

Method

SNPs

OR

95% CI

P value

Heterogeneity test Q (P value)

MR-Egger pleiotropy test Intercept (P value)

Allergic Rhinitis

Histidine

IVW

2

0.555

0.359−0.856

0.008

0.399

NA

 

Alanine

Wald ratio

1

0.307

0.108−0.875

0.027

NA

NA

 

Threonine

Wald ratio

1

0.2634

0.081−0.861

0.027

NA

NA

 

Lysine

Wald ratio

1

1.272

1.003−1.612

0.047

NA

NA

 

Maleate

Wald ratio

1

1.400

1.004−1.951

0.047

NA

NA

Asthma

Histidine

IVW

2

0.759

0.597−0.964

0.024

0.767

NA

 

Glycolate

Wald ratio

1

1.852

1.082−3.170

0.025

NA

NA

 

Tyrosine

IVW

3

0.742

0.567−0.972

0.030

0.559

0.686

 

O.Phosphocholine

Wald ratio

1

0.516

0.281−0.947

0.033

NA

NA

  1. (P < 0.05)
  2. OR: Odds Ratio, CIs: confidence intervals