The causal relationship between physical activity, sedentary time and idiopathic pulmonary fibrosis risk: a Mendelian randomization study

Table 1 Pleiotropy and heterogeneity tests of MR

Exposure	Test	Method	Effect size	P
Moderate to vigorous physical activity	Heterogeneity	Cochran's Q test (MR Egger)	1.131	0.89
	Heterogeneity	Cochran's Q test (IVW)	1.149	0.95
	Pleiotropy	MR-Egger regression (egger_intercept)	0.009	0.9
	Pleiotropy	MR-PRESSO global test	1.687	0.95
Average acceleration	Heterogeneity	Cochran's Q test (MR Egger)	13.976	0.6
	Heterogeneity	Cochran's Q test (IVW)	15.685	0.55
	Pleiotropy	MR-Egger regression (egger_intercept)	0.062	0.21
	Pleiotropy	MR-PRESSO global test	17.806	0.56
Sedentary time	Heterogeneity	Cochran's Q test (MR Egger)	7.335	0.06
	Heterogeneity	Cochran's Q test (IVW)	7.447	0.11
	Pleiotropy	MR-Egger regression (egger_intercept)	0.028	0.84
	Pleiotropy	MR-PRESSO global test	11.389	0.18

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