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Table 4 Association between paternal age (continuous, per 5-year increase) and lung function, stratified by breastfeeding

From: Association of advanced paternal age with lung function at school age

 

Crude coefficient β (95% CI)a

Adjusted coefficient β (95% CI)a

Breastfed ≥ 6 months ( n = 611)

 

 FVC (mL)

− 11.99 (− 30.84, 6.85)

− 8.75 (− 23.34, 5.83)

 FEV1 (mL)

− 14.79 (− 32.24, 2.65)

− 11.06 (− 24.42, 2.29)

 FEV1/FVC (%)

− 0.35 (− 0.88, 0.17)

− 0.37 (− 0.95, 0.21)

 FEF75 (mL/s)

− 21.10 (− 43.2, 1.00)

− 16.90 (− 39.49, 5.68)

 PEF (mL/s)

− 14.17 (− 65.51, 37.17)

2.69 (− 46.8, 52.17)

 FeNO (ppb)

0.69 (− 0.75, 2.13)

0.93 (− 0.67, 2.54)

Not breastfed or breastfed < 6 months ( n = 719)

 

 FVC (mL)

5.45 (− 10.24, 21.13)

4.31 (− 7.84, 16.47)

 FEV1 (mL)

− 0.68 (− 14.89, 13.52)

− 3.20 (− 14.58, 8.17)

 FEV1/FVC (%)

− 0.46 (− 0.86, − 0.06) *

− 0.60 (− 1.04, − 0.15) *

 FEF75 (mL/s)

− 19.48 (− 36.80, − 2.16) *

− 22.31 (− 40.75, − 3.87) *

 PEF (mL/s)

− 22.87 (− 62.41, 16.68)

− 29.94 (− 69.09, 9.2)

 FeNO (ppb)

− 0.54 (− 1.73, 0.65)

− 1.29 (− 2.58, 0.00)

  1. CI confidence interval, FVC forced vital capacity, FEV1 forced expiratory volume in 1 s, FEF75 forced expiratory flow at 75% of FVC, PEF peak expiratory flow, ppb parts per billion
  2. aPer 5-year increase in paternal age at birth, adjusting for age, sex, height, maternal age at birth, prematurity, birth weight, cesarean delivery, birth order, physician-diagnosed asthma, parental university education, parental allergic diseases, prenatal exposure to environmental tobacco smoke, and household income
  3. *P < 0.05 is bold
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Respiratory Research

ISSN: 1465-993X

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