Fig. 5
From: LncRNA SNHG16 promotes pulmonary fibrosis by targeting miR-455-3p to regulate the Notch2 pathway
SNHG16 regulated the expression of miR-455-3p. a SNHG16 mRNA wide-type (SNHG16 WT) and the mutated-type (SNHG16 MUT) in the miR-455-3p binding sites were shown. b Luciferase activity of HEK293T cells co-transfected with miR-455-3p mimics or NC mimics and luciferase reporters containing SNHG16 WT or SNHG16 MUT transcript were determined by dual-luciferase reporter assays. c Endogenous miR-455-3p precipitated by AGO2 upon overexpression of SNHG16 was determined by RIP assay. d Relative miR-455-3p was in different groups determined by qRT-PCR. Data were expressed as mean ± SD. **P < 0.01 vs control or anti-IgG; #P < 0.05 vs TGF-β1 + Ad sh-SNHG16; ##P < 0.01 vs anti-IgG, represent statistically difference