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Table 3 Pathology, cytokines and growth factors resulting when tracheal allografts are transplanted into the rat subcutaneous pouch

From: The heterotopic tracheal allograft as an animal model of obliterative bronchiolitis

  

Harvest time

Luminal

Epithelial

Changes in

  

Donor strain

Recipient strain

(days)

occlusion (%)

loss (%)

cytokines/GFs

n

Reference

BN

Lewis

14

26

  

n.r.

[15]

  

28

85

 

IL-2R ↑

  

BN

Lewis

9

 

50

 

8

[16]

  

14

Partial

100

 

8

 
  

21

100

100

 

8

 
  

28

100

100

 

8

 
  

56

100

100

 

8

 

BN

Lewis

21

100

100

 

5

[46]

BN

Lewis

3

 

Mild

At all time points:

5

[43]

  

7

  

IL-2 ↑, IFN-γ↑,

5

 
     

RANTES ↑, MCP-1 ↑

  
  

21

100

100

 

5

 

BN

Lewis

21

83

  

n.r.

[73]

BN

Lewis

21

83

100

 

5

[48]

BN

Lewis

7

30

19

RANTES ↑

5

[49]

  

21

90

100

RANTES ↑

5

 
  1. GFs, growth factors; IFN-γ, interferon-γ; IL, interleukin; IL-2R, IL-2 receptor; MCP, monocyte chemoattractant protein; n.r., not reported.