Figure 1
From: Role of epidermal growth factor receptor activation in regulating mucin synthesis
The mechanism of EGFR expression and activation. Stimulation of airway epithelial cells with TNF-α causes EGFR expression (the extracellular and intracellular parts of EGFR are shown). EGFR ligands (produced by epithelial or nearby cells) bind to EGFR, resulting in EGFR tyrosine phosphorylation and a subsequent downstream cascade, which causes mucin gene and protein expression.