Supplementary Table 1 Main functions: surfactant delivery and epithelial repair
From: Alveolar epithelial type II cell: defender of the alveolus revisited
Function/product | Functional significance | Reference |
Surfactant | ||
Synthesis | ||
Components of surfactant | ||
Phospholipids | Surface activity | [186] |
Surfactant proteins | ||
A | Tubular myelin formation | |
Defence | [33] | |
B | Absorption of lipid to monolayer | |
C | [86] | |
D | Defence | |
Components secreted together with surfactant | ||
Lysozyme | Defence | |
Plasmalogens | Protection against oxidation | [192] |
Cathepsin H | ||
Maturation | ||
Intracellular cathepsin H | Processing of SP-B | [194] |
Processing of SP-C | [50] | |
Secretion | ||
Signal receptors | ||
β-adrenergic receptors | ||
P1 purinoreceptors | ||
P2Y purinoreceptors | ||
Components of exocytosis apparatus | ||
Microtubules | [65] | |
Actin | [66] | |
Annexin II | [200] | |
Annexin IV | [201] | |
Annexin VII (= Synexin) | ||
Extracellular transformation | ||
α1-antitrypsin | [2048] | |
Convertase | Conversion of lipid monolayer into vesicles | |
Recycling | ||
Receptor of SP-A | [206] | |
Lamellar body lysosomal enzymes | ||
Alkaline phosphatase | Marker of type II cells | [207] |
α-glucosidase | [208] | |
α-mannose | [208] | |
Alveolar epithelial repair | ||
Proliferation | ||
Cyclin A | [209] | |
Cyclins D1, D2 | Proliferation, differentiation | [210] |
Cyclin dependent phosphokinases | Proliferation, differentiation | [210] |
PTHRP | Inhibition of proliferation | [211] |
Calmodulin | Proliferation, differentiation | |
Insulin-like growth factor (IGF)-binding protein2 | G1-arrest | [214] |
Differentiation | ||
Retinoic acid receptor | Inhibition of differentiation | [215] |
Aminopeptidase N | [216] | |
Apoptosis | ||
CD95 (receptor of Fas-ligand) | [134] | |
Fas-ligand | [138] | |
Bax | Pro-apoptotic peptide | [217] |
Bcl-2 | Anti-apoptotic peptide | [138] |
Caspase-3 | Execution caspase | [138] |